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butabarbital will lessen the extent or result of nifedipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Not known.butabarbital will minimize the extent or impact of midazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.butabarbital will lessen the level or result of diazepam intran